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Appendix A: Additional Figures and Tables. Appendix B: Estimands and Estimators Appendix C: Approximate sample size formula Fig A: SEIR model with vaccination. Fig B: Direct and indirect protection of a transmissible vaccine broken down by individual. Fig C: Required sample sizes, N_T*, depend on R₀ of the wildtype pathogen as well as the vaccine efficacy. Table A: Epidemiological parameter values. Table B: Estimated overall protection from and required sample sizes, N_T*, for trials comparing a transmissible vaccine to a traditional vaccine when cluster size n = 500. (PDF)