<i>DQ6</i> protection in T1D is enhanced amongst individuals with a low iKIR score.

<p>The cohort was stratified into individuals with high or low iKIR score using different iKIR score thresholds (1.5, 1.75, 2.0 and 2.5). The protective effect of <i>DQ6</i> was evaluated independently in each stratum using multivariate logistic regression with gender included as a covariate. <i>DQ6</i> is significantly protective (ln[OR] = -3.74, P = 1.05×10<sup>−157</sup>) in the UK-GRID cohort (Group = Whole cohort, unstratified analysis). Regression coefficients, p-values and cohort sizes are reported for the different strata. P-value for the unstratified analysis calculated using Wald-test, all other p-values calculated using a permutation test.</p> <p>(PDF)</p>