Summary results of TWAS fine-mapping in UK Biobank (down-sampled).

<p>The table summarizes the number of discoveries for each of the six disease traits (rows) in the reduced sample TWAS fine-mapping analysis of UK Biobank. A GWAS risk region (1<sup>st</sup> column) is defined as an LD block that harbors at least one genome-wide significant SNP (p-value < 5 × 10<sup>−8</sup>). A significant TWAS gene (2<sup>nd</sup> column) is defined as a gene with a marginal TWAS p-value < 0.05/14,388. A TWAS risk region (3<sup>rd</sup> column) is defined as an LD block that harbors at least one marginal TWAS significant gene. A risk region with GWAS or TWAS signals (4<sup>th</sup> column) is defined as an LD block that harbors at least one genome-wide significant SNP or significant TWAS gene. The last three columns list the number of genes discovered by each of the three methods. The number in the bracket is the number of identified genes that are located in a risk region with GWAS or TWAS signals. We used an estimated FDR threshold of 0.05 to declare significance for all methods in the fine-mapping analysis.</p> <p>(DOCX)</p>