More details on cis- <i>vs.</i> trans-regulation of iSoMAs genes.

(A) Detailed chromosome distribution and chromosome preference profiles of top 100 target isoforms of representative iSoMAs genes TP53 (left) and KRAS (right) across cancer types. P-values were derived from KS test for chromosome preference and are indicated above corresponding cancer types. Lhg19: the chromosome length distribution of the 24 chromosomes; Niso: number distribution of all isoforms across the 24 chromosomes. (B) Schematic of the hypergeometric test performed to determine cis-regulation of iSoMAs genes. (C) Number of cis-regulation iSoMAs genes determined at various significance levels for each cancer type as indicated. The cancer types, together with the number of iSoMAs genes with <i>P</i>>0.999 (potentially trans-regulation iSoMAs genes) and the number of all iSoMAs genes detected in each cancer type are indicated in the x-axis. (DOCX)