Mitigating the risk of low-titer group O-positive whole blood resuscitation in females of childbearing potential: toward a systems-based approach

The use of low-titer group O-positive whole blood (LTO+WB) in critically injured females of childbearing potential (FCPs) remains the subject of institutional hesitation. The Shock Whole Blood and Assessment of TBI (SWAT) secondary analysis study by Brito et al1 in this issue of TSCAO revealed that only 26.2% of women under age 50 years received LTOWB. These findings highlight the complexities surrounding a potential disparity in life-saving care, the ongoing uncertainty surrounding a treatment with potential for harm, and the need for standardized protocols. In comparison, men and women over age 50 years were more than twice as likely to receive LTO+WB.