Assessing the Interaction\nbetween Dodecylphosphocholine\nand Dodecylmaltoside Mixed Micelles as Drug Carriers with Lipid Membrane:\nA Coarse-Grained Molecular Dynamics Simulation

Integrating drugs into cellular membranes efficiently\nis a significant\nchallenge in drug delivery systems. This study aimed to overcome these\nbarriers by utilizing mixed micelles to enhance drug incorporation\ninto cell membranes. We employed coarse-grained molecular dynamics\n(MD) simulations to investigate the stability and efficacy of micelles\ncomposed of dodecylphosphocholine (DPC), a zwitterionic surfactant,\nand dodecylmaltoside (DDM), a nonionic surfactant, at various mixing\nratios. Additionally, we examined the incorporation of a mutated form\nof Indolicidin (IND) (CP10A), an anti-HIV peptide, into these micelles.\nThis study provides valuable insights for the development of more\neffective drug delivery systems by optimizing the mixing ratios of\nDPC and DDM. By balancing stability and penetration efficiency, these\nmixed micelles can improve the delivery of drugs that face challenges\ncrossing lipid membranes. Such advancements can enhance the efficacy\nof treatments for various conditions, including viral infections and\ncancer, by ensuring that therapeutic agents reach their intended cellular\ntargets more effectively.