StereoselectiveSynthesis of (<i>R</i>)‑all-<i>trans</i>-13,14-Dihydroretinol and -Retinoic Acid

Vitamin A (or all-<i>trans</i>-retinol) metabolites are involved in a wide range of cellular processes. However, the investigation of their biological role is hampered due to their very limited availability. Herein we report a stereoselective total synthesis of the vitamin A metabolites (<i>R</i>)-all-<i>trans</i>-13,14-dihydroretinol and -retinoic acid, applying an <i>E</i>-selective HWE olefination and a Ru(II) catalyzed intramolecular 7-<i>endo</i>-<i>dig</i> hydrosilylation as the key steps.