Indium Mediated Reformatsky-Type Allylation of N-<i>tert</i>-Butanesulfinyl Iminoester with 1,3-Butadiene

This study presents the indium-mediated\nthree-component radical\nReformatsky-type allylation of <i>N</i>-<i>tert</i>-butanesulfinyl iminoester with 1,3-butadiene. This novel approach\noffers a rapid synthesis pathway to valuable homoallylic noncanonical\namino acids, demonstrated with over 30 examples showing nice regio-\nand diastereoselectivity. Mechanism studies revealed that allylindium\ncomplexes served as key intermediates, formed through a single-electron\nreduction of allylic radicals by Indium species.