Palladium-Catalyzed\nStereospecific Glycosylation Enables\nDivergent Synthesis of N–O-Linked Glycosides

We present a versatile palladium-catalyzed glycosylation\nplatform\nthat enables facile access to structurally diverse N–O-linked\nglycosides with constantly excellent regio- and stereoselectivities.\nImportantly, this approach offers a broad substrate scope, low catalyst\nloadings, and outstanding chemoselectivity, allowing for the selective\nreaction of oximes/hydroximic acids over hydroxyl groups that would\notherwise pose challenges in conventional glycosylation methods. The\nsynthetic utility of this method is further exemplified through a\nrange of synthetic transformations and late-stage modification of\nbioactive molecules. Overall, our method provides an efficient toolkit\nfor the synthesis of N–O-linked glycosides, which will facilitate\ntheir subsequent biological evaluations.