Photoredox-Catalyzed\nRegioselective 1,3-Alkoxypyridylation\nof <i>gem</i>-Difluorocyclopropanes

Difluoromethylene and pyridine cores are very important\nstructural\nunits in medicinal chemistry. Herein, we report the development of\nphotoredox-catalyzed ring-opening and 1,3-alkoxypyridylation of <i>gem</i>-difluorinated cyclopropanes using 4-cyanopyrines and\nalcohols, employing cyclopropane radical cations as the key intermediate.\nThe reaction exhibits high regioselectivity under mild conditions\nand can also be practiced on gram-scale synthesis, telescoped reaction,\nand late-stage functionalization of biological molecules.