Prospects of ultrafiltration in supporting the Development of

\nDebridement is a critical step in wound healing, which involves removing necrotic or infected tissue from wounds Specific enzymes, including fibrinolytic protease from Metabacillus sp. CS-2 has shown anti-necrosis activity and potential as a wound debridement agent. However, efforts to enhance the enzyme’s activity to improve its performance as a debridement agent remain unexplored. This review highlights the potential of ultrafiltration to boost bacterial protease activity based on data from Google Scholar and PubMed. Using the dimension.ai database with keywords “ultrafiltration”, “bacterial protease”, and “protease activity”, a literature review over the last ten years was conducted, supported by network visualization via VOSviewer. The findings suggest that ultrafiltration is an important part of a study that should be conducted to support the development of Metabacillus sp. CS-2 protease as a debridement agent.\n