DMAP Catalyzed\nRing-Opening/Cycloaddition of Vinyl\nOxiranes with Activated Ketone Compounds to Construct the 1,3-Dioxolane\nSkeletons

The present work develops a DMAP-catalyzed [3 + 2] cycloaddition\nof vinyl oxiranes with activated ketone compounds, affording dioxolane\nderivatives with moderate to excellent yields. This approach represents\nthe first Lewis base (LB)-catalyzed ring-opening reaction of vinyl\nepoxides, simultaneously providing a rare oxygen-containing active\nintermediate in this field. The gram-scale preparation and facile\nderivatization of the cycloadduct highlight the significant synthetic\npotential of this strategy.