Photocatalytic\nRegioselective Redox-Neutral 1,3-Oxypyridylation\nof Aryl Cyclopropanes

Pyridines and cyclopropanes are important structural\nunits in chemistry.\nHerein, we introduce a photoredox-catalyzed approach for the ring\nopening and 1,3-oxypyridylation of aryl cyclopropanes using 4-cyanopyridines\nand carboxylic acids. This sequential process involves single-electron\noxidation of the aryl cyclopropane, leading to nucleophilic ring opening\nand radical pyridylation at the benzylic position. The redox-neutral\nreaction exhibits high regioselectivity under mild reaction conditions,\noffering a broad substrate scope and wide applicability.