Palladium(II)-Catalyzed\nEnantioselective Ring Opening\nof Oxabenzonorbornadienes via Domino Aminopalladation of Alkynylanilines

We report herein a robust enantioselective ring opening\ncoupling\nof oxabenzonorbornadienes via Pd(II)-catalyzed domino cyclization\nof alkynylanilines, which features the formation of three covalent\nbonds and two contiguous stereocenters with excellent enantio- and\ndiastereoselectivity and a broad substrate scope. The good functional\ngroup tolerance of this domino desymmetrization strategy enables efficient\nlate-stage transformation of natural product-derived alkynylanilines.\nThe resulting indolated dihydronaphthols could serve as a valuable\nplatform to streamline the diversity-oriented synthesis of other valuable\nenantioenriched tetrahydronaphthalene derivatives.