Isolation andBioinspired Synthesis of Lauenones Aand B, Skeleton-Rearranged Diterpenoids with Antiadipogenic Activityfrom <i>Croton laui</i>

Two skeleton-rearranged labdane diterpenoids, lauenones A (<b>1</b>) and B (<b>2</b>) were isolated from <i>Croton laui</i>. Their bioinspired synthesis was accomplished in 9 and 10 steps, respectively, without using any protecting groups. Key steps include a semipinacol rearrangement and a substrate-controlled one-pot reaction cascade involving photooxidation and aldol condensation. Notably, both lauenones A and B exhibit antiadipogenesis in 3T3-L1 adipocytes by downregulating the differentiation factors and liposynthesis enzymes at mRNA transcription and protein expression levels.