Catalytic Asymmetric\nReductive Amination for Axially\nChiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade

Herein we present an efficient chiral phosphoric-acid-catalyzed\natropoenantioselective asymmetric reductive amination of biaryl dialdehydes.\nThe process involves desymmetrization and the following kinetic resolution,\nwith a wide range of axially chiral aryl aldehydes obtained with high\noptical purities.

Publication Details

Journal
Figshare
Published
2024-08-19
DOI
https://doi.org/10.1021/acs.orglett.4c02540.s001
Primary Topic
Axial and Atropisomeric Chirality Synthesis
Type
article
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article

Catalytic Asymmetric\nReductive Amination for Axially\nChiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade

Figshare
Axial and Atropisomeric Chirality Synthesis
article

Catalytic Asymmetric\nReductive Amination for Axially\nChiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade

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Abstract

Herein we present an efficient chiral phosphoric-acid-catalyzed\natropoenantioselective asymmetric reductive amination of biaryl dialdehydes.\nThe process involves desymmetrization and the following kinetic resolution,\nwith a wide range of axially chiral aryl aldehydes obtained with high\noptical purities.

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Catalytic Asymmetric\nReductive Amination for Axially\nChiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade · Figshare (2024) | TGRS Research Map | TGRS