Rhodium(III)-Catalyzed\nRegioselective C4 Alkylation\nof Indoles with Nitroalkenes

The Rh­(III)-catalyzed indole C4–H bond addition\nto nitroalkenes\nis disclosed under mild and redox-neutral reaction conditions, offering\nstraightforward access to various 4-(2-nitroalkyl)­indoles (34 examples)\nwith excellent chemo- and regioselectivity. Furthermore, late-stage\ndiversifications and mechanistic studies were also performed.

Publication Details

Journal
Figshare
Published
2024-11-20
DOI
https://doi.org/10.1021/acs.joc.4c02236.s001
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
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article

Rhodium(III)-Catalyzed\nRegioselective C4 Alkylation\nof Indoles with Nitroalkenes

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Catalytic C–H Functionalization Methods
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Rhodium(III)-Catalyzed\nRegioselective C4 Alkylation\nof Indoles with Nitroalkenes

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Abstract

The Rh­(III)-catalyzed indole C4–H bond addition\nto nitroalkenes\nis disclosed under mild and redox-neutral reaction conditions, offering\nstraightforward access to various 4-(2-nitroalkyl)­indoles (34 examples)\nwith excellent chemo- and regioselectivity. Furthermore, late-stage\ndiversifications and mechanistic studies were also performed.

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Catalytic C–H Functionalization Methods
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Rhodium(III)-Catalyzed\nRegioselective C4 Alkylation\nof Indoles with Nitroalkenes · Figshare (2024) | TGRS Research Map | TGRS