Large-Scale,\nHigh-Density MicroLED Array-Based Optogenetic\nDevice for Neural Stimulation and Recording

Optogenetics has emerged as a pivotal\ntool in neuroscience,\nenabling\nprecise control of neural activity through light stimulation. However,\nthe current microLED arrays lack sufficient density and scalability.\nThis study proposes an innovative optogenetic device capable of integrating\nhundreds of microLEDs and electrocorticography (ECOG) electrodes.\nIndividual or multiple microLEDs in the device can be selectively\ncontrolled with a custom controller. The light intensity of microLEDs\ndecreases with increasing brain tissue penetration while maintaining\na low temperature rise during pulse stimulations. In addition, interference\nfrom microLED pulses on ECOG electrode recordings could be alleviated\nwith local mean subtraction data processing. The optogenetic device\nenables high-quality neural signal recording and triggers a significant\nenhancement in neural activity following light stimulation. Integration\nof microLED arrays and ECOG electrodes in the optogenetic device represents\na promising advancement in neuroscientific research, providing improved\nspatial and temporal recording and control over neural activity.