Alkylation of\nGlycine Derivatives through a Synergistic\nSingle-Electron Transfer and Halogen-Atom Transfer Process

Here, we present a versatile method for forming C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bonds, enabling the synthesis of\na range\nof natural and non-natural amino acids. This approach utilizes readily\navailable glycine derivatives and alkyl iodides, combining single-electron\ntransfer and halogen-atom transfer processes. The utility of this\nstep-economic and redox-economic C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bond formation is further highlighted in the late-stage\nsite-selective modifications of the glycine residue in short peptides.