CuI-Catalyzed Dearomatization/Peroxidation/CyclizationCascade of Pyrrole-Tethered Indoles

A mild CuI-catalyzed dearomatization/peroxidation/cyclization cascade of pyrrole-tethered indoles has been reached, providing peroxide-incorporated indolizino[8,7-<i>b</i>]indole derivatives in acceptable to good yields (46–76%). Dehydrogenated peroxide can be obtained by the use of a FeCl<sub>3</sub>/TBHP (<i>t</i>BuOOH)/2,2,2-trifluoroethanol (TFE) system at 50 °C.

Publication Details

Journal
Figshare
Published
2025-02-27
DOI
https://doi.org/10.1021/acs.joc.4c02977.s001
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
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article

CuI-Catalyzed Dearomatization/Peroxidation/CyclizationCascade of Pyrrole-Tethered Indoles

Figshare
Catalytic C–H Functionalization Methods
article

CuI-Catalyzed Dearomatization/Peroxidation/CyclizationCascade of Pyrrole-Tethered Indoles

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Abstract

A mild CuI-catalyzed dearomatization/peroxidation/cyclization cascade of pyrrole-tethered indoles has been reached, providing peroxide-incorporated indolizino[8,7-<i>b</i>]indole derivatives in acceptable to good yields (46–76%). Dehydrogenated peroxide can be obtained by the use of a FeCl<sub>3</sub>/TBHP (<i>t</i>BuOOH)/2,2,2-trifluoroethanol (TFE) system at 50 °C.

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Catalytic C–H Functionalization Methods
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