Organic Base-CatalyzedCascade Reaction of CF<sub>3</sub>–Iminopropargylic Alcoholswith Carboxylic Acids: anApproach to β‑CF<sub>3</sub> β‑Aminoenones

A novel approach to the synthesis of β-CF<sub>3</sub> β-aminoenones by the organic amine base-catalyzed reaction of CF<sub>3</sub>-iminopropargylic alcohols with carboxylic acids is reported. The advantages of the protocol are the ease of operation, available starting materials, and simple tertiary amine catalysts.

Publication Details

Journal
Figshare
Published
2025-02-06
DOI
https://doi.org/10.1021/acs.joc.4c02959.s001
Primary Topic
Fluorine in Organic Chemistry
Type
article
Field-Weighted Citation Impact
0.00
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article

Organic Base-CatalyzedCascade Reaction of CF3–Iminopropargylic Alcoholswith Carboxylic Acids: anApproach to β‑CF3 β‑Aminoenones

Figshare
Fluorine in Organic Chemistry
article

Organic Base-CatalyzedCascade Reaction of CF3–Iminopropargylic Alcoholswith Carboxylic Acids: anApproach to β‑CF3 β‑Aminoenones

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Abstract

A novel approach to the synthesis of β-CF<sub>3</sub> β-aminoenones by the organic amine base-catalyzed reaction of CF<sub>3</sub>-iminopropargylic alcohols with carboxylic acids is reported. The advantages of the protocol are the ease of operation, available starting materials, and simple tertiary amine catalysts.

Figshare
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Fluorine in Organic Chemistry
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Organic Base-CatalyzedCascade Reaction of CF<sub>3</sub>–Iminopropargylic Alcoholswith Carboxylic Acids: anApproach to β‑CF<sub>3</sub> β‑Aminoenones · Figshare (2025) | TGRS Research Map | TGRS