GSH Oligomer-Directed\nChiral Au-Helicoid Nanoparticles\nfor Discriminating Penicillamine Enantiomers

Preparing chiral plasmonic nanoparticles (NPs) with strong\nchiroptical\nresponses is crucial in numerous fields including constructing optical\nmaterials, chiral sensing, and chiral-dependent biological processes.\nHowever, precise regulation over the chiral optical activity and chiral\nconfiguration of plasmonic NPs is still a challenge. In this work,\nwe report Au helicoid NPs with different chiral structures and reversal\nchirality directed by the oligomeric structure of inducer glutathione\n(GSH). By precisely controlling the oligomeric structure of GSH and\nother synthetic parameters, we successfully prepared chiral Au helicoid\nNPs with a high anisotropy factor of 0.03. The obtained chiral Au\nNPs demonstrated an excellent performance in discriminating penicillamine\n(Pen) enantiomers. Our findings provide a construction strategy for\nchiral Au NPs and contribute insight into the regulation effect of\nchiral inducers on the growth of chiral metal NPs.