Organic Photoredox-Catalyzed\nSite-Selective Alkylation\nof Glycine Derivatives and Peptides via Infrequent 1,2-Hydrogen Atom\nTransfer of Amidyl Radicals

Herein, we disclose a visible-light-driven photoredox-catalyzed\nprotocol for site-selective alkylation of glycine derivatives via\n1,2-hydrogen atom transfer, which is distinguished by metal free and\nmild conditions, high chemoselectivity, and good functional group\ncompatibility. This protocol provides a unique approach for synthesizing\nvaluable α,β-diamino acid derivatives. Furthermore, the\npotential synthetic merit of this transformation is proven by a scale-up\nreaction and late-stage functionalization of peptides.