Copper-Catalyzed\nOne-Pot\nSynthesis of <i>N</i>,<i>N</i>‑4-Triphenylthiazol-2-amines

Herein,\nwe reported an efficient copper-catalyzed strategy for\nthe synthesis of <i>N</i>,<i>N</i>-4-triphenylthiazol-2-amines\nfrom bromoacetophenone, phenylthiourea and iodobenzene. This method\nfeatures good functional group tolerance, easy availability of starting\nmaterials and simplicity of operation, which provides an alternative\nmethod for the synthesis of 2-aminothiazoles.

Publication Details

Journal
Figshare
Published
2024-10-28
DOI
https://doi.org/10.1021/acs.joc.4c01417.s001
Primary Topic
Sulfur-Based Synthesis Techniques
Type
article
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Copper-Catalyzed\nOne-Pot\nSynthesis of N,N‑4-Triphenylthiazol-2-amines

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Sulfur-Based Synthesis Techniques
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Copper-Catalyzed\nOne-Pot\nSynthesis of N,N‑4-Triphenylthiazol-2-amines

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Abstract

Herein,\nwe reported an efficient copper-catalyzed strategy for\nthe synthesis of <i>N</i>,<i>N</i>-4-triphenylthiazol-2-amines\nfrom bromoacetophenone, phenylthiourea and iodobenzene. This method\nfeatures good functional group tolerance, easy availability of starting\nmaterials and simplicity of operation, which provides an alternative\nmethod for the synthesis of 2-aminothiazoles.

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Sulfur-Based Synthesis Techniques
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Copper-Catalyzed\nOne-Pot\nSynthesis of <i>N</i>,<i>N</i>‑4-Triphenylthiazol-2-amines · Figshare (2024) | TGRS Research Map | TGRS