Metal-Free Synthesis\nof 2‑(per)Fluoroalkyl-3-nitro\nIndoles via Intramolecular Cyclization of Amides

A metal-free intramolecular cyclization\nof N-acyl amides for the\nsynthesis of 3-nitro-2-(per)fluoroalkyl indoles is reported. Good\nfunctional group tolerance and a broad range of substrates are the\nfeatures of this approach. The developed method is easy to operate\nand is suitable for the preparation of 2-difluoromethyl/trifluoromethyl/perfluoroethyl/perfluoropropyl\nindoles in yields of 84 to 99%. Also, the application of this protocol\nin the gram scale is shown.

Publication Details

Journal
Figshare
Published
2024-09-12
DOI
https://doi.org/10.1021/acs.joc.4c01430.s001
Primary Topic
Fluorine in Organic Chemistry
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Metal-Free Synthesis\nof 2‑(per)Fluoroalkyl-3-nitro\nIndoles via Intramolecular Cyclization of Amides

Figshare
Fluorine in Organic Chemistry
article

Metal-Free Synthesis\nof 2‑(per)Fluoroalkyl-3-nitro\nIndoles via Intramolecular Cyclization of Amides

article en

Abstract

A metal-free intramolecular cyclization\nof N-acyl amides for the\nsynthesis of 3-nitro-2-(per)fluoroalkyl indoles is reported. Good\nfunctional group tolerance and a broad range of substrates are the\nfeatures of this approach. The developed method is easy to operate\nand is suitable for the preparation of 2-difluoromethyl/trifluoromethyl/perfluoroethyl/perfluoropropyl\nindoles in yields of 84 to 99%. Also, the application of this protocol\nin the gram scale is shown.

Figshare
Openalex Percentile: Top 73%
Fluorine in Organic Chemistry
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Metal-Free Synthesis\nof 2‑(per)Fluoroalkyl-3-nitro\nIndoles via Intramolecular Cyclization of Amides · Figshare (2024) | TGRS Research Map | TGRS