Suppression\nof Metastasis and Angiogenesis by Taxifolin\nRuthenium‑<i>p</i>‑cymene Loaded PLGA Nanoparticles\nin Lung Carcinoma

Flavonoid-based\norganometallic complexes were revealed\nto be novel\nbioactive compounds. The taxifolin ruthenium-<i>p</i>-cymene\nnanoparticle (TaxRu-NPs) was produced in this study, and the toxicological\nassessment was done prior to in vivo chemotherapeutic research. Furthermore,\nthe in vitro chemotherapeutic investigation used the A549 and NCI-H460\nlung cancer cell lines. The in vitro study found that TaxRu-NPs induced\napoptosis in lung cancer cells and hindered their ability to form\ncolonies and migrate. The in vivo study showed that treatment with\nTaxRu-NPs restored the histological structure of a normal lung with\nless hyperplasia and lymphocytic infiltration. Furthermore, the treatment\ndownregulated the angiogenic marker VEGF and the cell survival protein\nβ-catenin and upregulated apoptotic markers like p53 and caspase-3.\nTaxRu-NPs treatment additionally raised the apoptotic index and decreased\ncancer cell growth. Finally, TaxRu-NPs effectively alleviate lung\ncancer by activating p53-mediated apoptosis and preventing angiogenesis\nand metastasis by decreasing the VEGF/β-catenin pathway.