Cu-Catalyzed Electrochemical Activation of Nitromethane\nto Access Aldoxime-Substituted Nitrile Oxide for Huisgen Reaction

Here,\nwe report an electrochemical approach to generate an aldoxime-substituted\nnitrile oxide via the activation of nitromethane. The Cu-catalyzed\nHuisgen reaction of this 1,3-dipole with alkynes enables successful\npreparation of 48 new isoxazole aldoximes, which are typically challenging\nto synthesize by other methods, in 52 to 97% yields with excellent\nregioselectivity and chemoselectivity in a single step. Moreover,\n20 3,3′-bisisoxazoles are prepared from the isoxazole aldoxime\nproducts in good yields via a two-step sequence.