Development of Axially\nChiral Pyridylidene Amine Ligands\nand their Application in Pd-Catalyzed Enantioselective Allylic Substitution

A series of novel axially chiral pyridylidene amine (PYE)\nligands\nhas been developed, and their catalytic capability has been demonstrated\nin various highly efficient and enantioselective Pd-catalyzed asymmetric\nallylic substitutions. A density-functional theory (DFT) study explains\nthe preferential enantiocontrol in the key transition states of the\naxially chiral PYE ligand-promoted Pd-catalyzed allylic alkylation.