I<sub>2</sub>‑Promoted\nChemoselective Annulative\nCoupling of 2‑Aminobenzamides with Sulfoxonium Ylides: Easy\nAccess to Quinazolinones

A flexible and metal-free synthetic approach for synthesizing\n2-benzoyl\nquinazolinones and 2-aryl quinazolinones via molecular iodine-mediated\nannulative coupling of sulfoxonium ylides with 2-aminobenzamides has\nbeen disclosed. The method demonstrates remarkable chemoselectivity\nand efficiency, leading to high yields of 2-benzoyl quinazolinones\nand 2-aryl quinazolinones under optimized conditions. The broad substrate\nscope, scalability, and practical utility were highlighted through\ndiverse applications, including gram-scale reactions and the synthesis\nof biologically significant compounds such as tryptanthrin and the\nchemo/biosensor derivative.