Chitosan-Based\nComposite Aerogel with a Rapid Tissue\nHydration Layer-Triggered Response to Promote Hemostasis

Aerogels exhibit poor adhesion to wet tissue surfaces,\nwhich is\na significant factor that limits their hemostatic properties. In this\nwork, we propose a new method for investigating aerogel hemostatic\nmaterials by introducing the concept of the ‘rapid tissue hydration\nlayer-triggered property’ into the hemostatic material. A chitosan\nderivative (<i>Csde</i>) with a “swollen property”\nwas prepared via an amide reaction, followed by the incorporation\nof the extracted bletilla striata complex (<i>Bscai</i>)\ninto the chitosan derivative to fabricate the <i>Bscai/Csde</i> hemostatic material. The research results indicated that the <i>Bscai/Csde</i> hemostatic material exhibited a rapid tissue\nhydration layer-triggered response, outstanding hemostasis ability,\nas well as excellent hemocompatibility, antibacterial properties,\nand cytocompatibility. Additionally, the preparation method for the <i>Bscai/Csde</i> hemostatic material is straightforward, and the\nraw materials are readily available. Therefore, this study presents\na novel method for developing a hemostatic material method, and the\ncomposite aerogel hemostatic material demonstrates considerable potential\nfor future applications.