Ligand-PromotedRemote γ‑C(sp³)–H Chlorination andBromination of Alcohols

Herein, we report a Pd(II)-catalyzed protocol f-C(sp³)–H chlorination and bromination of aliphatic alcohols using NCS and NBS as the halogenating reagents. The addition of 2-pyridone ligand and base was crucial to the success of the reaction. The method showed excellent functional group tolerance. The gram-scale reaction and the facile removal of the directing group demonstrated its potential application in the synthesis of γ-chloro or bromo alcohols containing quaternary carbon.