Merging Photoinduced\nElectron Transfer with Hydrogen\nAtom Transfer: Formal β‑C(sp<sup>3</sup>)–H Pyridination\nof Carbonyls

In\nthis study, a novel approach that combines photoinduced\nelectron\ntransfer (ET) with hydrogen atom transfer (HAT) has been introduced\nfor the selective β-C(sp<sup>3</sup>)–H pyridination\nof carbonyl compounds. This method is notable for its absence of transition\nmetals and its ability to function under benign reaction conditions,\nresulting in a range of pyridinated carbonyl derivatives with consistently\nmoderate to good yields. The significance of this technique is further\nunderscored by its potential for the late-stage functionalization\nof pharmaceutically significant molecules. Mechanistic investigations\nconfirmed that the reaction proceeds via a radical-mediated pathway.