Pentafluorosulfanylation\nof Acrylamides: The Synthesis\nof SF<sub>5</sub>‑Containing Isoquinolinediones with SF<sub>5</sub>Cl

We\ndisclose herein an efficient and facile method for the synthesis\nof SF<sub>5</sub>-containing isoquinolinediones with an all-carbon\nquaternary stereocenter via intramolecular pentafluorosulfanylation\nof acrylamides using SF<sub>5</sub>Cl as a pentafluorosulfanylation\nreagent. The protocol proceeds under mild reaction conditions and\nenjoys a broad substrate scope, wide functional group compatibility,\nand high atom- and step-economy. A radical mechanism involving the\nSF<sub>5</sub> radical cascade addition/cyclization of acrylamides\nis proposed.