Lysosome-Targeted Polarity-Sensitive NIR Fluorescence\nProbe for Imaging Injured Lung and Liver in Diabetes

Diabetes is a chronic disease marked\nby high blood glucose. With\nthe progress of diabetes, complications gradually appear, and various\norgans may be affected. However, due to the lack of noninvasive in\nsitu detection probes, the diagnosis of organ damage caused by diabetes\nis significantly delayed, which will cause many complications that\ncannot be treated in time. Here, we report a BODIPY-based fluorescent\nprobe <b>SNL</b>, which can be used to detect lung and liver\ndamage caused by diabetes. By introducing methylpiperazine and extending\nthe conjugated system, <b>SNL</b> can locate lysosomes and exhibit\nabsorption and emission both in the near-infrared (NIR) region. In\naddition, <b>SNL</b> is sensitive to polarity and can be used\nfor sensitive detection of lysosomal polarity changes. Unexpectedly, <b>SNL</b> targets and images the lungs and liver of mice. Subsequently,\nhyperglycemia-stimulated cell models and diabetic mouse models were\nsuccessfully established, and <b>SNL</b> was utilized to reveal\nthat polarity can be used as a diagnostic signal of diabetic complications.\nNotably, <b>SNL</b> for the first time confirmed the lung injury\nand liver injury caused by diabetes using the fluorescent probes method,\nproviding a new approach for the diagnosis of diabetes complications.