Critical review on the assessments of green metric tools for Olmesartan medoxomil analytical methods: Case studies

• Explain green analytical chemistry tools. • Discuss the AES, AGREE, and BAGI criteria. • Evaluate the greenness assessment score for the case studies. Green chemistry metrics can incorporate features of analytical practices that adhere to the principles of green chemistry. Several metrics are available to evaluate the greenness of the analytical procedure, including the AES, AGREE, and BAGI. The current review article outlines the selected metrics used to determine case studies of Olmesartan, employing various analytical techniques, including UV spectrophotometry, HPLC, HPTLC, UPLC, LC-MS, and UPLC-MS, based on specific criteria. These criteria also include the advantages, disadvantages, and limitations of each technique. The analytical eco–scale, AGREE and BAGI values were in the range 79–86, 72–84, 66–68, 77, 75–89, 67–75; 0.6–0.71, 0.55–0.65, 0.58–0.65, 0.62, 0.65–0.66, 0.68–0.69; 77.5–82.5, 72.5–82.5; 75–77.5, 80, 75 – 80 and 80 respectively for UV spectrophotometry, HPLC, HPTLC, UPLC, LC-MS and UPLC-MS. The results are well-organised according to the criteria and have produced an excellent greener methodology. The new researchers could understand and use all the assessment tools for different purposes. Additionally, they can utilise it to develop new procedures, which could demonstrate a greener methodology for quantifying Olmesartan in various matrices.