An Axially Chiral\nQuinoline-2-Carboxylic\nAcid-Cu Catalyst\nfor Enantioselective Synthesis of <i>C</i><sub>2</sub>-\nand <i>C</i><sub>1</sub>‑Symmetric BINOLs

The in situ dimeric coordination\nof two chiral ligands bearing\nquinoline-2-carboxylic acid units and substituted BINOL backbones\nwith a copper ion generates a new chiral catalyst for oxidative homo-\nand cross-coupling of various 2-naphthols, enabling enantioselective\nsynthesis of a broad range of highly useful diversely substituted <i>C</i><sub>2</sub>- and <i>C</i><sub>1</sub>-symmetric\nBINOLs in up to 96% yield with good to excellent enantioselectivities\n(up to 98:2 e.r.).