Nickel-Catalyzed,\nAminoquinoline-Directed Chemo- and\nRegioselective Carboamination of Unactivated Olefins with Organoboronic\nAcids and Anthranils

A nickel-catalyzed three-component carboamination of\nunactivated\nalkenes with organoboronic acids and anthranils has been achieved\nfor the expedient synthesis of δ-aryl and γ-amino acid\nderivatives. The 8-aminoquinoline (AQ) directing group is crucial\nfor the success of the reaction, and anthranil serves as an arylnitrene\nprecursor in this conversion. This method features mild reaction conditions,\ngood chemo- and regioselectivity, and a broad substrate scope with\ngood functional group tolerance.