Synthesis of P‑Stereogenic Phosphinamides via\nNickel-Catalyzed Kinetic Resolution of H‑Phosphinamides by\nAlkenylation and Arylation

A nickel-catalyzed\nenantioselective cross-coupling for the synthesis\nof P-stereogenic phosphinamides has been developed. The asymmetric\nalkenylation and arylation of racemic H-phosphinamides using alkenyl\nand aryl bromides resulted in the formation of P-stereogenic N-phosphinyl\ncompounds with good yields and high enantioselectivities. This method\ntolerates a variety of functional groups, and its applications are\nexplored through scale-up reactions and product transformations.