A three-step chromatographic method for ultra-trace ^242mAm purification prior to ICP-MS analysis

Accurate determination of ^242mAm is critical for nuclear forensics and environmental radioisotope monitoring. To achieve high sensitivity in analyzing ultra-trace ^242mAm using mass spectrometry, it is imperative to eliminate interferences such as isobars, polyatomic ions, and bulk matrices. In this investigation, we developed a three-step chromatographic method utilizing TRU resin, NaBiO₃, and HDEHP resin based on the adsorption characteristics of the target elements and optimization of column conditions. Validation experiments demonstrated the thorough removal of interfering elements with high decontamination factors (DF), notably achieving a DF value of 1.4 × 10⁴ for Cm. The method is robust and suitable for sample preparation to accurately quantify ultra-trace ^242mAm in complex samples.