Additional file 7 of A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis
Supplementary Material 7: Figure S7: Chronic amyloidosis does not result in Aβ induced Tau hyperphosphorylation. A: Immunofluorescence staining for phosphorylated Tau T181and total Tau in hiNS of all 6 experimental conditions. B: Quantification of pTau181/total Tau ratio in hiNS indicates pTau modulation by hiMG independent of Aβ exposure. C: Soluble pTau181 was quantified using ELISA on supernatants from hiNSconfirms the lack of Aβ induced Tau hyperphosphorylation
Institutions
- University of British Columbia (CA)
- University of Toronto (CA)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- SickKids Foundation (CA)
- University College London (GB)
Publication Details
- Journal
- Figshare
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6084/m9.figshare.28862715.v1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00