Phytochemical analysis, antioxidant, antihemolytic and anti-inflammatory properties of ethanolic extract of <i>Cydonia oblonga</i> Mill. fruit

The aim of this study was the estimation and identification of some phenolic compounds, <i>in vitro</i> antioxidant, antihemolytic, and anti-inflammatory activities of ethanolic extract prepared from <i>Cydonia oblonga</i> Mill.fruit (QFEE). The amounts of polyphenols, flavonoids, and tannins contents were found to be 141.62 mg GAE/g of dry extract, 0.68 mg QE/g extract, and 50.73 mg TAE/g of extract, respectively. RP-HPLC analysis proved the identification of 8 compounds, including 7-hydroxyflavone as a major flavonoid. QFEE showed an interesting antioxidant activity using DPPH, hydroxyl radical, and iron chelating tests. Also, QFEE had an antihemolytic effect with an IC₅₀ of 1.58 mg/ml. Oral administration of QFEE at doses of 200 and 600 mg/kg on rats reduced the edoema induced by carrageenan. These results suggest that quince extract is an important source of antioxidants that can contribute to the anti-inflammatory effects.