Additional file 3 of Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

Supplementary Material 3: Fig. 3. Analysis of deep RNA sequencing data for MDA-MB-231 cells treated with 1 µM T-025. (A) PPIs analysis on downregulated genes related to cell migration. (B) The top 10 most important hub genes of the PPIs identified by CytoHubba in Cytoscape based on MCC algorithm. (C) The top 20 GO cellular components terms enriched in downregulated genes. (D) PPI network of the downregulated genes involved in focal adhesion

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Publication Details

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Figshare
Published
2025-01-01
DOI
https://doi.org/10.6084/m9.figshare.29671194
Primary Topic
Nuclear Structure and Function
Type
article
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0.00
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Additional file 3 of Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

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Nuclear Structure and Function
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Additional file 3 of Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

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Abstract

Supplementary Material 3: Fig. 3. Analysis of deep RNA sequencing data for MDA-MB-231 cells treated with 1 µM T-025. (A) PPIs analysis on downregulated genes related to cell migration. (B) The top 10 most important hub genes of the PPIs identified by CytoHubba in Cytoscape based on MCC algorithm. (C) The top 20 GO cellular components terms enriched in downregulated genes. (D) PPI network of the downregulated genes involved in focal adhesion

Figshare
Leiden University (NL), Leiden University Medical Center (NL)
Openalex Percentile: Top 61%
Nuclear Structure and Function
DOIOpen Access PDFOpenAlex
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Additional file 3 of Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC · Figshare (2025) | TGRS Research Map | TGRS