Seasonal variation in <i>Operculicarya decaryi</i> H. Perrier essential oil composition in correlation with its wound healing potential

Multidrug-resistant bacterial species and their untreatable infections threaten human health worldwide. The four seasons’ essential oils (EOs) of <i>Operculicarya decaryi</i> were investigated against methicillin resistant <i>Staphylococcus aureus</i> MRSA. Limonene was the major component identified in <i>O. decaryi</i> EOs followed by methyl cinnamate. <i>O. decaryi</i> autumn essential oil (<i>Od</i>ao) has a robust antibacterial effect against MRSA. Camphor, carvone, <i>p</i>-cymen-7-ol, <i>α</i>-terpinen-7-al, cryptone, and caryophyllene oxide were highly correlated to the observed activity. <i>Od</i>ao exhibited a significant wound healing ability and remarkable anti-inflammatory activity in human adult dermal fibroblasts (HDFa) cells inflammatory model. A significant reduction in the microbial counts recovered from the spleens of the groups treated by either Fusidic acid or <i>Od</i>ao in <i>in vivo</i> skin infection murine model was observed. This study is the first record for the phytochemical composition of <i>Od</i>ao and its antimicrobial, anti-inflammatory and wound healing activities, suggesting camphor, carvone, and <i>p</i>-cymen-7-ol as top highly correlated components.