Additional file 1 of Short-term mortality after opioid initiation among opioid-naïve and non-naïve patients with dementia: a retrospective cohort study

Additional File 1: Tables S1-S10 and Figures S1-S7. Table S1 - ICD-10 codes and search criteria of dementia and its subcategories. Table S2 - RxNorm codes of opioid ingredient. Table S3 - Variable definition. Table S4 - ICD-10 codes and inclusion criteria of comorbidities. Table S5 - RxNorm codes, categories, and inclusion criteria of medications. Table S6 - Secure GPT-3.5 Turbo prompt for potential causes of death identification. Table S7 - Descriptive statistics of opioid-exposed patients, comparing initiation group and continuation group in primary cohort on comorbidities and medication exposure. Table S8 - Descriptive statistics of the dementia/mild cognitive impairment cohort based on post-diagnosis opioid exposure status. Table S9 - Descriptive statistics of opioid-exposed patients, comparing initiation group and continuation group in replication cohort. Table S10 - Notes, GPT Responses, and Health Condition Categories of Mismatches Between Specified Principal Diagnoses at the Time of Death and GPT Responses. Figure S1 - Flowchart of cohort and exposure group selection in the replication cohort. Figure S2 - Study design and definition of exposure groups. Figure S3 - 180-day survival probability curves comparing initiation group and continuation group in primary and replication cohorts. Figure S4 - Sensitivity analysis comparing first-time opioid users to long-term continuation group in primary and replication cohort. Figure S5 - Strong opioid-specific and weak-opioid specific 14-day survival probability curve comparing initiation group and continuation group in primary and replication cohort. Figure S6: MCI-specific and dementia-specific 14-day survival probability curve comparing initiation group and continuation group in primary and replication cohort. Figure S7 - Inpatient-specific and outpatient-specific 14-day survival probability curve comparing initiation group and continuation group in primary and replication cohort. Figure S8 - Post-hoc supplementary analysis of short-term mortality associated with opioid initiation in patients with preexisting pneumonia and pneumonia development risk following opioid initiation in patients without preexisting pneumonia in primary and replication cohort.