Additional file 1 of Risk thresholds for soft versus hard cardiovascular disease outcome models for initiating statin therapy among Chinese adults: a cost-utility analysis

Additional file 1: Supplemental Method—CHEERS 2022 Checklist. Figures S1–S14. Fig. S1 Structure of the Markov model; Fig. S2 Calibration plots for CKB hard and soft ASCVD models after recalibration; Fig. S3 Observed vs. simulated probabilities of all events over 10 years; Fig. S4 GBD vs. simulated age-sex-specific all-cause mortality; Fig. S5 One-way sensitivity analyses for soft ASCVD model threshold of 18% vs. 19%; Fig. S6 One-way sensitivity analyses for hard ASCVD model threshold of 10% vs. 11%; Fig. S7 One-way sensitivity analyses for soft ASCVD model threshold of 13% vs. 14% in population aged 30–59 years; Fig. S8 Cost-utility acceptability curves for soft ASCVD threshold strategies in population aged 30–59 years; Fig. S9 One-way sensitivity analyses for hard ASCVD model threshold of 9% vs. 10% in population aged 30–59 years; Fig. S10 Cost-utility acceptability curves for hard ASCVD threshold strategies in population aged 30–59 years; Fig. S11 One-way sensitivity analyses for soft ASCVD model threshold of 20% vs. no treatment in population aged 60–75 years; Fig. S12 Cost-utility acceptability curves for soft ASCVD threshold strategies in population aged 60–75 years; Fig. S13 One-way sensitivity analyses for hard ASCVD model threshold of 15% vs. no treatment in population aged 60–75 years; Fig. S14 Cost-utility acceptability curves for hard ASCVD threshold strategies in population aged 60–75 years. Tables S1–S8. Table S1 Disease progression inputs used in the cost-utility model; Table S2 Baseline characteristics of participants with soft or hard ASCVD outcomes occurred during follow-up in CKB study; Table S3 Baseline characteristics of high-risk population defined by optimal thresholds for soft and hard ASCVD models; Table S4 Cost-utility of ASCVD threshold strategies for hard ASCVD model by age; Table S5 Cost-utility of ASCVD threshold strategies for soft ASCVD model by region; Table S6 Cost-utility of ASCVD threshold strategies for hard ASCVD model by region; Table S7 Cost-utility of ASCVD threshold strategies for soft ASCVD model by sex; Table S8 Cost-utility of ASCVD threshold strategies for hard ASCVD model by sex.