Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments

A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (¹H,¹³C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (<i>E</i>)-5-aryl-3-[(4-thioxo-4<i>H</i>-chromen-3-yl)methylene]furan-2(3<i>H</i>)-ones exist only in the <i>E</i>-configuration. Their <i>in vitro</i> antibacterial activity against <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> was studied in liquid nutrient media by the serial dilution method. The results showed that (<i>E</i>)-5-(4-chlorophenyl)-3-[(4-thioxo-4<i>H</i>-chromen-3-yl)methylene]furan-2(3<i>H</i>)-one and (<i>E</i>)-5-(4-methoxyphenyl)-3-[(4-thioxo-4<i>H</i>-chromen-3-yl)methylene]furan-2(3<i>H</i>)-one demonstrated the best <i>in vitro</i> antibacterial properties against the bacterial culture <i>Escherichia coli</i>.