Endothelial activation and stress index (EASIX) as a predictive biomarker for survival in patients with T-cell lymphoma

The Endothelial Activation and Stress Index (EASIX) has emerged as a significant prognostic indicator in various hematological malignancies. However, its role as a predictive biomarker in T-Cell Lymphoma remains unestablished. The purpose of this study is to assess the clinical relevance of EASIX in predicting Overall Survival (OS) and Progression-Free Survival (PFS) among T-cell lymphomas patients. A retrospective analysis was conducted on 117T-cell lymphomas patients diagnosed between January 2010 and September 2021 at the Affiliated Hospital of Xuzhou Medical University. The study included measurements of Lactate Dehydrogenase (LDH), Creatinine, and Platelet counts. The EASIX score was calculated using the formula: LDH [U/L] × Creatinine [mg/dL] / Platelets [10⁹ cells/L]. The median age of the patient cohort was 52 years, with a range of 12 to 85 years. The optimal threshold for EASIX, determined by the Receiver Operating Characteristic (ROC) analysis for OS, was identified as 1.66. Patients with a high EASIX score exhibited significantly reduced median OS and PFS compared to those with a low EASIX score (9.3 months versus not reached, <i>P</i> &lt; 0.001; and 5.7 months versus 24.1 months, <i>P</i> &lt; 0.001). Multivariate Cox regression analysis revealed that a high EASIX score is an independent adverse prognostic factor for OS, with a hazard ratio of 3.033 (95% Confidence Interval, 1.442-6.379; <i>P</i> = 0.003). The findings of this study suggest that the EASIX score may serve as a prognostic biomarker for poor OS in T-cell lymphomas, warranting further investigation.