Additional file 13 of Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes

Additional file 13: Supplementary Figure 5. Normalized insulin secretion of bacterial peptides. Screen of nine bacterial peptides on insulin secretion at low glucose (baseline, 2 mM glucose) and high glucose (20 mM) compared to vehicle control in INS-1 β-cell line. Bar plots depicting absolute values (normalized to protein content) of the baseline (A) and high-glucose (B) insulin secretion for each of the screened bacterial peptides. C) Difference in stimulation index (ratio of insulin secretion at high glucose to insulin secretion at low glucose) of all nine bacterial peptides compared to vehicle control. Peptides AQYLLESLVK, LLELTPALYVGK and DNTYATLIVPVGTK (genus Neisseria) nominally decreased stimulation index. Data was screened with multiple unpaired t-tests and depicted as % difference from vehicle control values of individual batches (batches indicated by symbols). D) Stimulation index (absolute and % change from vehicle control) of peptide ALLENLQEGSVIK compared to vehicle control. Data was tested with unpaired t-test (batches indicated by symbols).