Novel sesquiterpenoids from <i>Colletotrichum camelliae</i> LP76, a predominant endophytic fungus from <i>Camellia taliensis</i>

Two new sesquiterpenoids, designated as collcameins A (<b>1</b>) and B (<b>2</b>), alongside four previously identified compounds (<b>3</b>-<b>6</b>), were successfully extracted from the solid-state fermentation of <i>Colletotrichum camelliae</i> LP76, a predominant endophytic fungus found within its leaves of <i>Camellia taliensis</i> cultivated ancient tea tree. Their chemical structures were determined through various spectroscopic techniques and by comparing the results with available literature for elucidation. To clarify the stereochemical configurations of <b>1</b> and <b>2</b>, extra X-ray diffraction crystallography was employed, both featuring a rare presilphiperfolane-type architecture. Additionally, the anti-inflammatory and antifungal activities were also assessed. As a result, compound <b>1</b> and <b>2</b> exhibited significant inhibitions against <i>A. brassicicola</i>, being comparable with the positive control (thiabendazole).