Additional file 1 of PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands

Supplementary Figure 1: Overall pipeline of the PandaOmics TargetID approach. Transcriptomic data from the UChicago cohort was combined with two publicly available ACC datasets (GSE88804 and GSE59701) into a single Meta-analysis that was passed into the PandaOmics prioritization engine for target discovery. Given the limited prior knowledge about ACC, we utilized only the set of 13 AI-based Omics scores for the target search. Ranked list of target candidates was filtered with respect to the protein class, druggability assessment, target development level and tissue specificity